I feel your pain! My skin is always dry and in the winter it gets unbearable. My suggestion is to always put on cream with glycerin and oils before you go out and never go out when your hands are wet. Although you probably already know that. Try vitamins A, C and E and maybe some Omega acids? The best hand cream I've had was based on olive oil with Omega-3 and 6. Another favorite of mine was based on honey.